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Neggers et al., confirmed these observations, highlighting that over 70% of children affected by ASD showed positivity to these autoantibodies and may benefit from targeted folinic acid supplementation (Neggers, 2014

However, since valproate may interact with these or other concurrently administered AEDs as well as other drugs, periodic plasma concentration determinations of concomitant AEDs are recommended during the early course of therapy [seeDrug Interactions (7)]