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The combined activities of these microorganisms lead to the development of a stable micro-ecosystem, which is essential for preserving the health of the female reproductive system ( Lactobacillus is the predominant beneficial bacterial species, which maintains the acidic environment through the secretion of lactic acid and other metabolic products, thereby inhibiting the growth of harmful pathogens ( Lactobacillus bacteria are the primary species within the vaginal microbiota, and their dominance is considered an indicator of vaginal health

Thus, it is feasible to include immunosuppressive agents into the scaffold system and modulate early immune reactions that are directly against newly implanted islets

[23] Niacinamide Since niacin is an essential nutrient, one would expect it to be safe when administered during pregnancy at doses meeting the recommended daily allowance (RDA)

Seleem et al., 2016)