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Some variants are assigned as P/LP based on classification as high prediction of loss-of-function based on protein effects (e.g., nonsense, frameshift, large deletions, etc.)

During dialysis, patients experience subnormal plasma/serum free carnitine concentrations [13] with plasma levels dropping by 60% with a slow replacement from carnitine stores such as from skeletal muscle during the interdialytic period

[DOI] [PMC free article] [PubMed] [Google Scholar] 308.Chang JL, Gong J, Rizal S, Peterson AL, Chang J, Yao C, et al

It has to be stressed that several features make carnitine an optimal vehicle for moving acyl groups: at first, the carnitine derivatives are more stable and less reactive with respect to the acyl-CoA (Ramsay and Arduini, 1993)