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GABA is able to compete with glutamate for oxidation in astrocytes (McKenna and Sonnewald 2005) and is extensively metabolized to support the synthesis of glutamine (Andersen et al

Wu Y-Y, Gou W, Yan Y, Liu C-Y, Yang Y, Chen D, et al

Response: We thank the commenter for this recommendation and refer the commenter to the policies set forth in 428.301, 428.302, and 428.303 and discussed later in this final rule regarding rebate reductions for certain Part D rebatable drugs currently in shortage, likely to be in shortage, or experiencing a severe supply chain disruption, as authorized under section 1860D-14B of the Act

were found to be prevalent in non-westernized communities suggesting host lifestyle relating to healthier food habits