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reported that dual-targeted therapy utilizing AMPK-activating drugs and vascular endothelial growth factor/programmed cell death 1 blockade may be a new treatment option for ovarian cancer focusing on metabolic vulnerability [66]

As many as 5% of patients who end up being diagnosed with vitamin B12 deficiency have blood B12 concentrations above a commonly used cut-off of about 150 mol/L, and even more have abnormal methylmalonic acid (MMA) or homocysteine levels, which are signs of functional B12 deficiency even if overt symptoms are not apparent

Theoretical concerns about chronic peptide administration including potential immunogenicity (antibody formation), accumulation in tissues, or long-term effects on neuroendocrine regulation have not been systematically addressed

Clinical manifestations in RA patients primarily involve joint lesions, with initial symptoms including joint stiffness, swelling, and pain [6, 7]