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Because if you are not making thyroid hormones, you are not making sex hormones and you are not making adrenal hormones then you are just flattened out all over the place like that would be sort of the, I think the gold standard of diagnosing this hypothetical loss of these nutrients in the brain

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Look Ahead Research Group Four-year change in cardiorespiratory fitness and influence on glycemic control in adults with type 2 diabetes in a randomized trial: the Look AHEAD Trial Diabetes Care 36 5: 1297-303

Activation of the mTOR pathway upregulates the expression of TFRC and FPN, which reduces the net accumulation of intracellular iron, lowers the release of labile iron and regulates iron homeostasis (50)