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The probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 exerts significant neurotrophic effects on MPTP-induced PD mouse models, and its mechanism is mainly achieved through inhibiting ferroptosis, alleviating oxidative stress, improving intestinal microbiota imbalance, and enhancing intestinal barrier integrity (263)

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Similarly, in the pathogenesis of MS, peripheral immune cells penetrate the BBB into the brain and destroy myelin membranes and neurons (Sweeney et al

Conclusions Thus far, the frontier of research delineating ceramides as bioactive drivers of DKD remains minimally explored