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However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo

The Neelakantan 2018 study in Biochemical Pharmacology reported that 5-Amino-1MQ administration to C57BL/6 mice on a 60% kcal-from-fat high-fat diet produced concentration-dependent reductions in fat mass and adipose-tissue NNMT enzymatic activity without significant changes in lean mass or food intake [1]

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Beta-3 adrenergic receptors, the primary target of AOD-9604, are highly expressed in white and brown adipose tissue but have minimal presence in appetite-regulating brain regions