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In prior studies we quantified H2AX foci per nucleus as a function of radiation dose and corresponding stimulated saliva secretion data at 12 weeks post-irradiation which is the gold standard test for radioprotection 51

Suppression of the pathogen-induced H 2 O 2 burst by the NADPH oxidase inhibitor diphenylene iodonium (DPI) prevented cell death whereas low millimolar concentrations of exogenous H 2 O 2 triggered HR-PCD in a calcium-dependent manner (Levine et al., 1994, 1996)

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