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Studies have shown that X-ray irradiation reduces KGN cells viability, alters mitochondrial morphology, induces intracellular iron accumulation, and triggers lipid peroxidation, ultimately leading to ferroptosis (Zhao et al., 2023)

doi: 10.1073/pnas.92.15.7001 65 PengX

This missense mutation is located in the third intracellular loop of SST5, a critical region for G protein coupling, and functional studies have demonstrated that mutant R240W receptor failed to mediate the inhibition of GH release and cell proliferation induced by SSTR5 agonist, although it retained the ability to inhibit intracellular cAMP levels, as the result of a loss of coupling with G oA protein but not with the other G proteins activated by wild type SSTR5, e.g., G i1, i2, i3 and G oB (11, 42)

Rao, S., Gerondakis, S., Woltring, D