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Dosage: Establishing the ideal dosage and timing for administering phytochemicals to realize therapeutic advantages for TBIs is a complex task, given that distinct polyphenols can have differing pharmacokinetics and mechanisms of action

Before making the diagnosis of PFIC, in the paediatric population, other cholestasis disorders should always be considered in the differential diagnosis, including biliary atresia, choledochal malformations, congenital endocrine disorders, inborn errors of metabolism (mainly during the neonatal period) as well as autoimmune liver diseases, drug-induced cholestasis and other genetic diseases in older children [72]

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