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Other metabolic side effects could be hypokalemia (low potassium levels in the body), extreme thirst, rapid weight gain, frequent urination and/or unexplained bleeding or bruising

R 2 , R 3 , R 4 , and R 5 are independently selected from the group consisting of: H, C 1-4 alkyl, halogen-substituted C 1-4 alkyl, NR 9 R 10 , and CN

What made it even more effective is that it did not affect the activity of any other enzymes in the metabolic cycles which reduced the risks of any potential side-effects