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Potential targets of intranodal therapy include intranodal vaccination with lipid nanoparticle (LNP)-mRNA constructs (85, 86) and intranodal delivery of tumor-antigen pulsed dendritic cells (87)

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When Conventional Pain Treatment Fails If pain persists despite medications, injections, or physical therapy, it is often a sign that: Inflammation is being driven by systemic factors Tissue damage is not healing adequately The nervous system remains stuck in a pain-sensitive state Foundational supports like nutrition, sleep, and recovery are insufficient At this point, continuing to suppress symptoms without addressing root causes can prolong suffering rather than resolve it