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Similarly, the first in vivo imaging studies in humans, confirmed an increase in OS and a simultaneous decrease in GSH levels in the motor cortex of patients with ALS (with an age of 65.2 9.4 years, and a mean disease duration of 25.8 17.1 months) compared to the controls [106, 107]

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A key consideration of exosomes is that the challenges in extracting biological fluid-derived exosomes, for example, in plasma, where enrichment of biological molecules and various exosome species exists, thereby an issue like the corona effect occurs (Voke et al., 2025)

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