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For example, melanoma cells resistant to targeted kinase inhibitors and immunotherapy become sensitive to ferroptosis, thereby enhancing the efficacy of targeted and immune therapies (Tsoi et al., 2018)

FOXO3a itself induces a set of atrophy-related genes, specifically the muscle-specific ubiquitin ligases, MAFbx and MuRF-1, which promote the breakdown of the myofibrillar apparatus [17]