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Archived (PDF) from the original on October 10, 2011

However, the effects of supplementing long-term are unknown, and high doses could have risks

Some studies have shown that breast cancer patients often have increased serum levels of PGE2 and proinflammatory cytokines, including TNF-, IL-1, IL-6, and CRP, which exacerbates the progression of cancer cachexia

More recently, DddA-derived cytosine base editors (DdCBEs) have further enhanced the precision of mtDNA editing by enabling C-to-T conversions without generating double-strand breaks, thereby providing a new toolkit for the direct correction of mutant mitochondrial genomes [547]