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2 Ferroptosis 2.1 Definition and characteristics of ferroptosis In 2.2 Molecular mechanisms of ferroptosis 2.2.1 Iron metabolism Iron is an essential physiological element, and its distribution and levels can significantly impact physiological processes ( 2+ ) generates large amounts of hydroxyl radicals through Fenton and iron-catalyzed Haber-Weiss reactions, catalyzing the generation of ROS, which in turn leads to the development of LP ( 2+ is produced through intestinal absorption or erythrocyte degradation and then oxidizes to iron (Fe 3+ )

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Moreover, bi-allelic JAM2 variants result in brain calcification, which could be attributed to dysfunction of solute transport (Schottlaender et al., 2020)