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The upregulation of BDNF signaling in animal models appears to improve the survival of dopaminergic neurons when given prior to PD induction or result in partial restoration of dopaminergic transmission [230]

Nonetheless, several studies suggest that presynaptic 5-HT 1A autoreceptors are also involved to reduce EPS ( 5-HT 3 receptors function as cation (Na + , K + , and Ca 2+ )-permeable ion channels and excite target neurons ( 3 receptors reduced haloperidol-induced EPS (e.g., catalepsy and bradykinesia) ( Figure 5 )