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In mice, 125 I-labeled SOD1-containing nanoparticles display increased stability in blood and in the brain, and improved accumulation in brain tissues, in comparison with non-cross-linked complexes and native SOD1 (Klyachko et al., 2012)

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In mouse models has established that APOE suppresses HMG-CoA reductase within the cholesterol synthesis pathway, leading to substantial intracellular accumulation of acetyl-CoA, the precursor for cholesterol biosynthesis (198)

However, some patients experience nausea as a temporary side effect, which may be less disruptive if it occurs during morning hours when food intake is lighter