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The genetic architecture of mitochondrial dysfunction encompassing both mtDNA and nuclear DNA mutations creates combinatorial complexity that no single model system adequately represents

Mutations in the gene for TDP-43 cause familial ALS in humans and the ALS-like phenotype in transgenic animals [117]

Particular focus could be devoted to thioredoxins (and enzymes involved in its synthesis and redox pathways) and NADPH (with the enzymes involved in NADPH biosynthesis)

ROS-scavenging hydrogels synergize with neural stem cells to enhance spinal cord injury repair via regulating microenvironment and facilitating nerve regeneration