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This article is for informational and research purposes only

Conducting First-in-Human clinical trials presents notable challenges due to their role as the initial Phase 1 studies, emphasising the importance of careful design and prioritising participant safety

Results Structural determination We fused thermostabilized BRIL at the N-terminus of the ghrelin receptor and applied the NanoBiT tethering strategy to improve complex stability and homogeneity (Supplementary Fig