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Across human trials, the MK-677 IGF-1 response is one of the most reproducible findings

doi: 10.1007/s00431-015-2644-z

2 The high rate of drug and toxin delivery to the kidney, due to its high renal blood flow (accounting for about 25% of cardiac output), exposes the kidney to elevated concentrations of these substances, which can lead to nephrotoxicity