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In vitro and pre-clinical studies also support its therapeutic potential

Physiol Behav 90(1):2128 Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D (2018) Effects of creatine supplementation on cognitive function of healthy individuals: a systematic review of randomized controlled trials

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Gastrointestinal side effects are common upon initiation of metformin therapy but can also begin anew in patients who have taken metformin for many years