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Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS) To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has required a Risk Evaluation and Mitigation Strategy (REMS) for these products

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They act more as an occlusive to prevent hydration loss from the surface of lips, rather than introducing hydration back in. Many lip balms may also contain irritating ingredients which can make dry skin worse, including menthol, essential oils, and fragrance

doi: 10.1038/s41574-018-0096-z 105 LatourteAJaulerrySCombierACherifiCJouanYGrangeTet al