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The choice of suitable linker chemistry is often based on intuition, but the significant pH difference between endosomes and the extracellular space (pH 2) makes it easier to achieve selective release

The expression of these metastasis initiation genes and their targets predicts a poor prognosis in particular types of cancer [11]

If this system is disrupted, such as by selective small-molecule inhibitors, like iFSP1, or by gene deletion, the loss of FSP1 function promotes ferroptosis