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The data simply isn't there yet

Preclinical studies have indicated that these compounds markedly improve intervertebral disc structure and suppress inflammatory responses in animal models of IDD, highlighting their potential clinical applications (47,88)

HIF-1 activation not only promotes metabolic reprogramming in tumor cells (e.g., enhancing glycolysis) but also induces vascular endothelial growth factor (VEGF) expression, leading to new blood vessel formation that supplies additional oxygen and nutrients to tumor cells (51)