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Naunyn Schmiedebergs Arch Pharmacol 281, 34155

36 The expression of nerve growth factor (NGF) and brainderived neurotrophic factor (BDNF) as well as other neuropeptides such as calcitonin generelated peptide (CGRP) are well known mediators in the nociceptive neurotransmission and are most likely responsible for the discogenic pain

However, prolonged or repeated exposure to stress can lead to HPA axis dysfunctiona state of dysregulation that affects the brain, body, and emotional well-being