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These drugs mediate the release of DAMPs following hepatocyte injury, which are sensed by, for example, Kupffer cells (KCs), activating innate immune receptors to trigger intracellular events leading to the release of pro-inflammatory mediators, cytokines, and chemokines, and then recruit neutrophils and monocytes to the blood in a sterile inflammatory process

The first study that described TRPM2 contribution to neuropathic pain used partial sciatic nerve ligation and spinal nerve transection animal models [113]

6.4.2 Novel microbiota-targeted therapeutics The development of novel therapeutics based on gut microbial mechanisms is emerging

Singh, V