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doi: 10.1016/j.cmet.2020.10.011 66 StockwellBRFriedmann AngeliJPBayirHBushAIConradMDixonSJet al

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The abnormal release of Ca 2+ from the mitochondria to the cytosol leads to the activation of microglia, neuroinflammation, and finally, cell death [29, 93]