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Within neurons, excess Fe + undergoes Fenton or HaberWeiss reactions, generating hydroxyl radicals that attack DNA, proteins, and lipid membranes, thereby inducing ROS and lipid peroxidation (183)

Graft integration was further evaluated macroscopically by observing the anastomotic sites for vascularization, tissue continuity, and the absence of lumen collapse or stenosis

Furthermore, synthetic -carotene (10100 M) may reduce the phosphorylation of JAK2 and STAT3, suggesting that its anti-inflammatory effect could be mediated through the inhibition of the JAK2/STAT3 signaling pathway, and it also reduces the phosphorylation of NF-B, JAK2, STAT3, JNK, and p38 in murine macrophage cell line RAW264.7 and murine peritoneal macrophages obtained from BALB/c mice [30], which are activated by LPS [31,32]

Heme oxygenase modulates oxidant-signaled airway smooth muscle contractility: role of bilirubin