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[8] Overall, these side effects are short-lived and manageable, often improving by slowing the rate of administration or taking breaks during an intravenous infusion if needed

Also, avoid waxing the treated skin

doi: 10.1038/nchembio.72 20 ShiHJiangYYangYPengYLiC

It is plausible that GSTs serve two distinct roles in the development of drug resistance via direct detoxification as well as acting as an inhibitor of the MAP kinase pathway