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When toxic exposure or chronic inflammation is too high, Phase 1 rapidly uses up the liver's glutathione reserves, causing Phase 2 to come to a screeching halt

Funding The study was supported in part by a research grant from PSC Partners 72 12 to O.W.-Z, the Israeli Science Foundation 1879/21 grant to O.W.-Z and grants from the Fred and Suzanne Biesecker Liver Center at the Childrens Hospital of Philadelphia to O.W.-Z and R.G.W

Meanwhile, to substantiate the protective role of serotonin in experimental APAP-induced liver injury, we reloaded Tph1-/- mice with serotonin by injecting its precursor 5-HTP 3 days beforehand