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Some doctors believe that MTHFRs influence on health is overstated and that many individuals with mutations live healthy, symptom-free lives

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doi:10.1016/j.jacadv.2023.100643 Higdon J

Clientized GST-S tail constructs containing either a Thr1273Asp or Thr1273Glu substitution showed 17-fold higher affinity for the -COPI subunit (a marker for the intact coatomer complex) than the wild-type GST-S tail construct (Fig