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Nat Rev Neurosci 15(1):4353 Yamada ES, Respondek G, Mssner S, De Andrade A, Hllerhage M, Depienne C et al (2014) Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice

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Frster resonance energy transfer spectroscopy revealed that Pb 2+ can displace Ca 2+ from the C2 domain in the presence of lipid membranes and inhibit the activity of protein kinase C (PKC)

Its also crucial to follow the manufacturers recommendations on the product label while ashwagandha is generally considered safe, excessive intake may cause side effects such as vomiting or diarrhea