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Since SPRMs affect basic cell programming in hormone-sensitive tissues (not just the uterus) and are known to change endometrial architecture in novel ways, are they associated with an increased risk for cancer SPRMs are now being administered in Europe, so well be paying close attention to outcomes there

[DOI] [PubMed] [Google Scholar] 5.Sikiric P., Rucman R., Turkovic B., Sever M., Klicek R., Radic B., Drmic D., Stupnisek M., Misic M., Vuletic L.B., et al

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Effectiveness In head-to-head studies, people on tirzepatide lost more weight than those on semaglutide especially at higher doses