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These cells have also been purified using the four-step iodixanol gradient described in OptiPrep Application Sheet C36 (see above) [21]

Parents should arrange an evaluation if a pigmented lesion: Appears suddenly Changes in size, shape, or color Develops irregular borders Bleeds or ulcerates Becomes painful Persists without a clear explanation Although oral melanoma is extremely rare in children , any suspicious pigmented lesion deserves professional assessment