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Studies have shown that changes in the gut microbiota down-regulate the expression of tight junction (TJs) proteins, leading to impaired intestinal barrier and bloodbrain barrier function, allowing biomacromolecules and microorganisms to penetrate the barrier, which in turn triggers neuroinflammatory responses (118)

Maintaining iodine homeostasis within this narrow therapeutic window is thus crucial

SELENOPs hippocampal function may be mediated through Zinc homeostasis, demonstrated in an Alzheimer mouse model (Yue et al., 2020)

That's a meaningful distinction when you consider what happens the moment you stop using the drug and blood flow returns to normal