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MSC therapy improves the severity of DSS-induced colitis by modulating gut microbiota, immune responses, and the ferroptosis pathway [303]

This sphere includes not only the intestinal epithelium, but also hepatic metabolism, sympathetic and parasympathetic nerve activity, endocrine, and cytokine secretions and metabolites of microbial origin [46]

Collectively, these immune-balancing effects decrease inflammation more generally and prevent the chronic activation cycles that lead to the progression of colitis ( A second primary mechanism of action of polysaccharides is to regulate the signaling pathways that determine the expression of genes involved in inflammation, oxidative stress, cell death and turnover of epithelial cells, and repair of the mucosa

Increased risk of hyperlipidemia in patients with major depressive disorder: a population-based study