glutathione methionine reaction Modelling changes in homeostasis as a function of quinone redox metabolism Critical Roles of the Cysteine–Glutathione

RBC eNOS is situated near the membrane cytoskeleton and shares key features with endothelial eNOS, including its dependence on L-arginine, oxygen, and the cofactor tetrahydrobiopterin (BH4) for NO production

In addition to this, there are various factors contributing to oxidative stress in FRDA, including mitochondrial labile iron, NRF2 expression, lipid peroxidation, and Ca 2+ homeostasis, which means therapeutics may need to combat a number of these factors to overcome oxidative stress

The copper is not freely available to catalyze reactions with other species at physiological pH

Several studies used glutamine in dipeptide form or in combination with other substances such as maltodextrin or other amino acids (alanine and cysteine)