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Factors responsible for the liver's contribution to drug metabolism include that it is a large organ, that it is the first organ perfused by chemicals absorbed in the gut, and that there are very high concentrations of most drug-metabolizing enzyme systems relative to other organs

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A second abnormality is a lack of sensory-motor integration, which is related to mild sensory complaints in patients with focal dystonias and may be responsible for some of the motor dysfunction

Oct 2 2023;14(19):8951-8963