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The remaining 15 firms responded to the document request and received warning letters based on their (inadequate) responses

This is why precursors like levodopa are used which can cross the BBB and are metabolized and converted into dopamine in the brain

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The possibility that the developed transporter-utilizing (pro)drugs and nanocarriers can interfere with the homeostasis of endogenous substrates of the transporters should be investigated to address safety issues