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Additionally, proteolysis targeting chimeras (PROTACs) offer a novel approach to modulate ferroptosis: PROTACs targeting ACSL4 or Nrf2 have been developed to either induce ferroptosis (in renal cell carcinoma) or enhance antioxidant defense (in CKD), respectively, with improved specificity compared to small-molecule inhibitors

These transmembrane proteins connect the internal cytoskeleton to the extracellular matrix, enabling cells to sense and respond to their environment

The presence of high levels of VEGF-C and tumor lymphangiogenesis is associated with immunosuppression but might also indicate better efficacy for ICB treatment

Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2