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Int J Mol Sci 18(4):776

As immune cells age, particularly T cells, mitochondrial efficiency declines, leading to reduced ATP production, increased ROS generation, and impaired mitophagy

GHK-Cu in a topical formulation mimics this signal

Iron overload can induce profound mitochondrial dysfunction, characterized by impaired mitochondrial respiration, elevated mtROS production, mitochondrial membrane depolarization, and mitochondrial swelling [84, 85]