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In addition, hypoxia induces MDR in several cancers, as described earlier, and hypoxia-related genes, specifically HIFs, could serve as potential biomarkers for identifying hypoxia-induced drug resistance

Although the systemic nature of these interventions complicates mechanistic dissection, it has been reported that nutrient deprivation robustly enhances autophagic flux and facilitates LDs turnover 52

The lymphatic system is a crucial site for immune responses, so nanodrugs are prone to come into contact with the immune environment, which enhances their capture by immune cells, thereby improving the efficiency of their entrance into the lymph nodes

Measurement of serum creatinine and cystatin C are more convenient and rapid tests for evaluating kidney function