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Angiotensin IV (Val 1 -Tyr 2 -Ile 3 -His 4 -Pro 5 -Phe 6 ) is an endogenous hexapeptide fragment of the renin-angiotensin system, historically considered a metabolite of angiotensin II but subsequently shown to have independent procognitive activity in rodent models

Despite considerable progress in the field of psychopharmacology, traditional antidepressant therapies persistently exhibit significant shortcomings, such as delayed therapeutic onset, suboptimal rates of remission, elevated instances of partial response, and adverse side-effect profiles (2, 3)

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