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(2018) demonstrated that dysregulation of downstream Rab substrates of LRRK2 resulted in neurodegeneration of dopaminergic neurons in the mammalian brain

Giles FJ, Kantarjian HM, Kornblau SM , Thomas DA, Garcia-Manero G, Waddelow TA, David CL, Phan AT, Colburn DE, Rashid A, Estey EH

As each approach targets only one aspect of the underlying pathophysiology, a single mechanism is unlikely to achieve optimal clearance

Additionally, deficiencies of HDAC1 and HDAC2 can reduce cell survival via decreasing the acetylation status of H3K56ac, H4K16ac and H4K91 [68], suggesting the positive effects of HDAC1 and HDAC2 on cell survival