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The factors affecting rate, extent and distribution into the brain are discussed and a brief description of the in silico , in vitro , in situ and in vivo methods used to measure BBB transport are presented

The brain tissue obtained was weighed and PBS was added in order to ensure a weight (g) to volume (mL) ratio of 1:9

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simultaneously with tall cutting) a strong dose-dependent bleeding time reduction was consistently demonstrated in both mice and rats