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Cell 184 , 12991313.e1219 (2021)

Processing methods can be roughly divided into four categories, such as pretreatment, water preparing, fire preparing, and water-fire preparing (Wang, 2003)

Stromal interaction molecule 1 (STIM1) detects ER calcium depletion, translocates to ER-plasma membrane junctions, and activates Ca 2+ release-activated channels (CRAC) by tethering Orai proteins, triggering CaMKK activation, which phosphorylates AMPK at Thr172