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This MMP-1 inhibition occurs through interference with AP-1 transcription factor binding to the MMP-1 promoter region, reducing collagen degradation rates in dermal matrices

Flow cytometric analysis revealed that CD4 + and CD8 + T cells from the blood and BALF of patients with COVID-19 ARDS had high levels of PD-1 expression, a sign of potential exhaustion and dysfunction (Extended Data Fig

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Synthesis of -glutamylcysteine in the chloroplast by GCL directly supports production of glutathione by plastid GS, but requires transport of the dipeptide to the cytosol for the cytosolic GS and movement of glutathione between organelles and the cytosol (Pasternak et al., 2008