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For the remaining 1012 articles, the full text was retrieved and critically reviewed

Furthermore, silencing gankyrin in TNBC cells disrupted the formation of the gankyrin/MDM2 complex, hindered the degradation of p53, increased SLC7A11 expression, impeded cysteine uptake, and decreased GPX4 production

93 These findings suggest that BH 4 deficiency and decreased eNOS activity cause endothelial dysfunction in elderly subjects and in patients with hypertension through an increase in oxidative stress